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Obstetric complications (OCs) are associated with cognitive and brain abnormalities observed in patients with schizophrenia. Gyrification, a measure of cortical integrity sensitive to events occurring during the prenatal and perinatal periods, is also altered in first-episode psychosis (FEP). We examined the relationship between OCs and gyrification in FEP, as well as whether gyrification mediates the relationship between OCs and cognition.
Methods
We examined differences in the Local Gyrification Index (LGI) for the frontal, parietal, temporal, occipital, and cingulate cortices between 139 FEP patients and 125 healthy controls (HCs). Regression analyses explored whether OCs and diagnosis interact to explain LGI variation. Parametric mediation analyses were conducted to assess the effect of LGI on the relationship between OCs and cognition for FEP and HC.
Results
Significant LGI differences were observed between FEP patients and HC in the left parietal and bilateral cingulate and occipital cortices. There was a significant interaction between OCs and diagnosis on the left cingulate cortex (LCC) that was specific to males (p = 0.04) and was driven by gestational rather than intrauterine OCs.
In HCs, OCs had a direct effect on working memory (WM) (p = 0.048) in the mediation analysis, whereas in FEP, we observed no significant effect of OCs on either verbal or WM.
Conclusions
OCs interact with diagnosis to predict LCC gyrification, such that males with FEP exposed to OCs exhibit the lowest LGI. OCs influence WM, and LCC gyrification may mediate this relation only in HC, suggesting a differential neurodevelopmental process in psychosis.
This paper reports a study that investigated how first language (L1) reading comprehension, L1 low-level skills, working memory capacity, and reading anxiety are related to the accuracy of responses and completion time in a second language (L2) reading test. The data obtained from Hungarian secondary school learners of English showed that anxiety related to processing the L2 reading text, time pressure, and the response tasks as well as L1 reading comprehension scores and backward digit span were significant predictors of L2 reading scores. L1 low-level skills did not contribute significantly to L2 reading accuracy. Higher levels of reading-related anxiety were associated with slower reading, and L2 learners with concurrently lower levels of L1 and L2 reading ability needed more time to complete the reading test. These findings highlight that L2 reading tests should be flexibly timed so that everyone, including test takers with literacy-related difficulties such as dyslexia, can demonstrate their abilities.
Individuals can intentionally process task-relevant information while ignoring task-irrelevant information. This study aims to investigate how to promote forgetting of task-irrelevant information through noninvasive brain stimulation, utilizing direct suppression and thought substitute inhibition mechanisms.
Methods
Participants were cued to either remember task-relevant information while forgetting task-irrelevant information (IR condition) or to forget task-irrelevant items while remembering task-relevant information (IF condition). High-frequency rTMS was applied to activate the left ventrolateral prefrontal cortex (VLPFC, n = 32), right dorsolateral prefrontal cortex (DLPFC, n = 32), or vertex cortex (control condition, n = 32).
Results
Compared to vertex stimulation, (1) The Left VLPFC stimulation promoted the memory of task-relevant information in the IR condition, and resulted in a memory deficit for the task-irrelevant information in the IF condition (active forgetting). (2) The Right DLPFC stimulation promoted the forgetting of task-irrelevant information in the IF condition (active forgetting) and facilitated the memory of task-relevant information in the IR condition.
Conclusions
Stimulating left VLPFC or right DLPFC can promote active forgetting. Noninvasive brain stimulation can effectively regulate memory control.
Fully updated for the second edition, this text remains a comprehensive and current treatment of the cognitive neuroscience of memory. Featuring a new chapter on group differences in long-term memory, areas covered also include cognitive neuroscience methods, human brain mechanisms underlying long-term memory success, long-term memory failure, implicit memory, working memory, memory and disease, memory in animals, and recent developments in the field. Both spatial and temporal aspects of brain processing during different types of memory are emphasized. Each chapter includes numerous pedagogical tools, including learning objectives, background information, further reading, review questions, and figures. Slotnick also explores current debates in the field and critiques of popular views, portraying the scientific process as a constantly changing, iterative, and collaborative endeavor.
Describe the social, cognitive, and biological influences on adolescent decision-making; understand the risk and reward systems of the brain and how these can be influenced by different contexts; evaluate the roles of peer groups, executive functions, and sex differences in adolescent behaviour.
Describe different types of memory and how they develop; explain how early experiences are remembered and why they are forgotten; understand why a limited memory can be beneficial for learning.
Statins are among the most prescribed medications worldwide. Both beneficial (e.g. antidepressant and pro-cognitive) and adverse (e.g. depressogenic and cognitive-impairing) mental health outcomes have been described in clinical studies. The underlying neuropsychological mechanisms, whether positive or negative, are, however, not established. Clarifying such activities has implications for the safe prescribing and repurposing potential of these drugs, especially in people with depression.
Methods
In this double-blind, randomized, placebo-controlled experimental medicine study, we investigated the effects of simvastatin on emotional processing, reward learning, working memory, and waking salivary cortisol (WSC) in 101 people at-risk for depression due to reported high loneliness scores (mean 7.3 ± 1.2 on the UCLA scale). This trial was largely conducted during periods of social distancing due to the COVID-19 pandemic (July 2021–February 2023), and we employed a fully remote design within a UK-wide sample.
Results
High retention rates, minimal outlier data, and typical main effects of task condition (e.g. emotion) were seen in all cognitive tasks, indicating this approach was comparable to in-person testing. After 28 days, we found no statistically significant differences (F’s < 3.0, p’s > 0.20) for any of the measures of emotional processing, reward learning, working memory, and WSC.
Conclusions
Study results do not substantiate concerns regarding adverse neuropsychiatric events due to statins and support the safety of their prescribing in at-risk populations. Although other unmeasured cognitive processes may be involved, our null findings are also in line with more recent clinical evidence suggesting statins do not show antidepressant or pro-cognitive efficacy.
A negated proposition can be expressed linguistically and mathematically. The current study examined the one-step and two-step procedure accounts from the perspective of the practice effect and working memory by comparing performance in two simple linguistic and mathematical verification tasks. Two online experiments were conducted with simple verification tasks over 10 practice sessions: a figure-equation task (e.g., ● ≠ ▲) and a figure-sentence task (e.g., ● is not ▲). Although reaction times in the equation task were faster than in the sentence task, both tasks showed that reaction times in negations took longer than those in affirmations regardless of the sameness of the figures in the target propositions (i.e., TA < FN and FA < TN) in both experiments, and the trend was not changed by the practice. The similar trends across the tasks, regardless of the practice, support the two-step procedure account, in which participants first evaluate the positive argument of negation and then reverse the response in negative propositions. Furthermore, high correlations between performance in the tasks and both verbal and spatial working memory tasks suggest that verification judgments may involve not only language processing but also more general cognitive processing.
Offspring of parents with bipolar disorder (BD offspring) face elevated risks for emotional dysregulation and cognitive deficits, particularly in working memory. This study investigates working memory deficits and their neural correlates in BD offspring.
Methods
We assessed 41 BD offspring and 25 age-matched healthy controls (HCs) using a spatial N-back task and task-related functional magnetic resonance imaging (fMRI).
Results
Compared to HCs, BD offspring exhibit reduced accuracy and lower signal-detection sensitivity (d′) on the 1-back task. fMRI reveals hyperactivation in the right intracalcarine cortex/lingual gyrus (ICC/LG) in BD offspring, particularly during the 1-back condition. Psychophysiological interaction (PPI) analyses show reduced connectivity between the right ICC/LG and the left postcentral gyrus in BD offspring as task load increases from 0-back to 1-back. This connectivity positively correlates with 1-back task performance in HCs but not in BD offspring. Additionally, using bilateral dorsolateral prefrontal cortex (DLPFC) as regions of interest, PPI analyses show diminished condition-dependent connectivity between the left DLPFC and the left superior frontal gyrus/paracingulate cortex, and between the right DLPFC and the left postcentral gyrus/precentral gyrus in BD offspring as the task load increases.
Conclusions
These findings suggest that BD offspring exhibit working memory deficits and impaired neural connectivity involving both sensory processing and higher-order cognitive systems. Such deficits may emerge at a genetically predisposed stage of bipolar disorder, underscoring the significance of early identification and intervention strategies.
In this chapter we touch on the idea of inter-learner variability in outcome (i.e., how far learners get) as well as rate of acquisition among different learners. We then link these issues to the idea of individual differences as explanatory factors. We focus on the most studied: motivation, aptitude, and working memory.
This study focused on the relative contributions of cognitive aptitudes to the incidental learning and automatization of mini-language grammar. Over three sessions, participants (N = 45; first language [L1] Polish; age range: 19–35) completed computerized training in MiniItaliano as well as tasks tapping into working memory, general intelligence, and language analytic ability (LAA). The overt aim of the training was to comprehend messages placed in the context of an Italian supermarket; however, its actual goal was to acquire the target syntactic rules (i.e., subject-verb agreement, gender agreement, word order). The final session included a surprise post-test with untimed and timed grammaticality judgment tasks (GJTs) as measures of explicit and automatized knowledge, respectively. Results showed that performance on both tasks was predicted by LAA over and above other cognitive and control measures. Additionally, scores on the untimed GJTs were related to reliance on (self-discovered) rules, while timed GJTs involved general IQ.
This study tracked the referential production of 25 Japanese-English returnee children for 5 years upon their return to Japan from an English-dominant environment (Mean age = 9.72 at the time of return) and compared their referential strategies to 27 Japanese monolinguals and 27 English monolinguals, age-matched to the returnee’s age at time of return. Returnees used more redundant noun phrases (NPs) in both languages to maintain references compared to monolingual peers. In English, no changes in NP use were noted over time, but increased exposure to English led to fewer redundant NPs when maintaining references. In their native Japanese (L1), returnees used less NPs for maintaining references and more NPs for reintroducing references, indicating improved reference tracking longitudinally. In sum, returnees’ referential production is more sensitive to L1 re-exposure effects than second language (L2) attrition and crucially, increased L2 exposure minimizes redundant referent production among bilingual returnee children.
This chapter reviews findings about the effects of aging on memory. Coverage includes working memory, encompassing processes such as refreshing and inhibition, as well as explicit and implicit long-term memory, and prospective memory. Within the topic of explicit long-term memory, specific topics include the levels of processing framework, subsequent memory paradigms, recollection, source memory, associative memory and binding, semantic memory, false memory, autobiographical memory, memory and future thinking, reactivation, controlled processes in long-term memory, event boundaries, and pattern separation.
Working memory refers to actively holding information in mind during a relatively short period of time, typically seconds. During working memory paradigms, information is actively kept in mind during the delay period. Working memory has been associated with activity in the lateral prefrontal cortex, the parietal cortex, and sensory processing regions. Section 8.1 details the brain regions that store the contents of working memory during the delay period. In Section 8.2, the evidence is evaluated that claims to link working memory with the hippocampus. Section 8.3 considers the brain timing commonly associated with working memory. In Section 8.4, brain activity associated with working memory that oscillates at particular frequencies is considered, which primarily includes alpha activity and gamma activity. In Section 8.5, changes in brain activity are highlighted that have been linked to training-related increases in working memory capacity.
The comprehension of irony involves a sophisticated inferential process requiring language users to go beyond the literal meaning of an utterance. Because of its complex nature, we hypothesized that working memory (WM) and fluid intelligence, the two main components of executive attention, would be involved in the understanding of irony: the former by maintaining focus and relevant information active during processing, the latter by disengaging irrelevant information and offering better problem-solving skills. In this eye-tracking reading experiment, we investigated how adults (N = 57) process verbal irony, based on their executive attention skills. The results indicated a null (or indirect) effect for WM, while fluid intelligence directly modulated the comprehension and processing of irony during reading. As fluid intelligence is an important individual-difference variable, the findings pave the way for future research on developmental and clinical populations who tend to struggle with nonliteral language.
The General Theory of human memory is the most prominent result of the cognitive revolution in psychology. Despite its role in modern memory research, the General Theory is not well understood. This book describes the General Theory of human memory and applies it to numerous empirical phenomena. It details the prominent architectures for formally modeling the flow of information among the proposed memory structures using the search of associative memory (SAM) and the retrieving effectively from memory (REM) models.
A central question in the second language (L2) processing literature has been whether and under what conditions readers reactivate copies of syntactic movement operations at structurally defined gap sites. The present study contributes to the debate by examining the role of similarity-based interference in processing intermediate copies in long-distance dependencies with either three similar description noun phrases (NPs) (the nurse, the doctor, the patient) or two similar (the nurse, the doctor) and one dissimilar NP (John). Sixty-nine advanced L2 readers of English with either French (+ wh-movement) or Persian (− wh-movement) as their L1 and 33 native English readers (+ wh-movement) participated in a self-paced reading task involving long-distance dependencies. The results indicate that L2 readers process wh-dependencies in the same way as native readers, both in structures with similar and dissimilar NPs. This suggests that highly advanced L2 readers reactivate moved elements at inter-causal boundaries and process long-distance wh-dependencies in the same way as native readers, especially when the NPs involved in a dependency relation are sufficiently distinguishable.
English-speaking children sometimes make errors in production and comprehension of biclausal questions, known as “Scope-Marking Errors”. In production, these errors surface as medial wh questions (e.g., What do you think who the cat chased? (Thornton, 1990)). In comprehension, children respond to questions like How did the boy say what he caught? by answering what was caught (de Villiers & Roeper, 1995). These errors resemble wh-scope marking questions, attested in languages like German. Together, these errors suggest temporary adoption of multiple UG-licensed grammars (e.g., Yang, 2002). However, Lutken et al. (2020) found that children who make these errors in production do not necessarily make errors in comprehension and vice versa. They suggest these errors stem from children’s immature processing mechanisms. This article examines children’s production, comprehension, and processing capabilities, specifically working memory (WM). We find a correlation between WM and error rate and suggest separate causes for production and comprehension errors.
Attention-deficit/hyperactivity disorder (ADHD) patients exhibit characteristics of impaired working memory (WM) and diminished sensory processing function. This study aimed to identify the neurophysiologic basis underlying the association between visual WM and auditory processing function in children with ADHD.
Methods
The participants included 86 children with ADHD (aged 6–15 years, mean age 9.66 years, 70 boys, and 16 girls) and 90 typically developing (TD) children (aged 7–16 years, mean age 10.30 years, 66 boys, and 24 girls). Electroencephalograms were recorded from all participants while they performed an auditory discrimination task (oddball task). The visual WM capacity and ADHD symptom severity were measured for all participants.
Results
Compared with TD children, children with ADHD presented a poorer visual WM capacity and a smaller mismatch negativity (MMN) amplitude. Notably, the smaller MMN amplitude in children with ADHD predicted a less impaired WM capacity and milder inattention symptom severity. In contrast, the larger MMN amplitude in TD children predicted a better visual WM capacity.
Conclusions
Our results suggest an intimate relationship and potential shared mechanism between visual WM and auditory processing function. We liken this shared mechanism to a total cognitive resource limit that varies between groups of children, which could drive correlated individual differences in auditory processing function and visual WM. Our findings provide a neurophysiological correlate for reports of WM deficits in ADHD patients and indicate potential effective markers for clinical intervention.
The neural correlates of working memory (WM) in schizophrenia (SZ) have been extensively studied using the multisite fMRI data acquired by the Functional Biomedical Informatics Research Network (fBIRN) consortium. Although univariate and multivariate analysis methods have been variously employed to localize brain responses under differing task conditions, important hypotheses regarding the representation of mental processes in the spatio-temporal patterns of neural recruitment and the differential organization of these mental processes in patients versus controls have not been addressed in this context. This paper uses a multivariate state-space model (SSM) to analyze the differential representation and organization of mental processes of controls and patients performing the Sternberg Item Recognition Paradigm (SIRP) WM task. The SSM is able to not only predict the mental state of the subject from the data, but also yield estimates of the spatial distribution and temporal ordering of neural activity, along with estimates of the hemodynamic response. The dynamical Bayesian modeling approach used in this study was able to find significant differences between the predictability and organization of the working memory processes of SZ patients versus healthy subjects. Prediction of some stimulus types from imaging data in the SZ group was significantly lower than controls, reflecting a greater level of disorganization/heterogeneity of their mental processes. Moreover, the changes in accuracy of predicting the mental state of the subject with respect to parametric modulations, such as memory load and task duration, may have important implications on the neurocognitive models for WM processes in both SZ and healthy adults. Additionally, the SSM was used to compare the spatio-temporal patterns of mental activity across subjects, in a holistic fashion and to derive a low-dimensional representation space for the SIRP task, in which subjects were found to cluster according to their diagnosis.