This chapter examines the urban and architectural transformation of Carthage in Late Antiquity, focusing on how the city evolved under Roman, Vandal and Byzantine rule between the fourth and seventh centuries. It discusses Carthage’s role as a political, economic and religious hub in the Mediterranean, emphasising the continuity of its strategic and commercial significance, particularly as a centre for grain production and trade. The study details how Carthage’s harbours, warehouses and marketplaces adapted to shifting imperial priorities. It also explores urban planning, noting how the city’s grid layout, monumental basilicas and elite residences reflected both Roman traditions and late antique adaptations. Religious transformation is another central theme, with a focus on the growth of Christian architecture, including churches, martyr shrines and cemetery basilicas. The chapter reassesses the impact of Vandal rule (439–533 CE), challenging traditional narratives of decline by presenting evidence of continued economic activity and urban maintenance. Under Byzantine rule (533–698 CE), Carthage experienced renewed investment in fortifications, infrastructure and religious buildings, though signs of urban contraction emerged by the seventh century. Thus this chapter demonstrates that Carthage remained a dynamic and resilient city despite political upheavals and its eventual conquest by Islamic forces.