We study buoyant miscible injections of dense viscoplastic fluids into lighter Newtonian fluids in inclined closed-end pipes, at the high-Péclet-number regime. We integrate experiments involving camera imaging and ultrasound Doppler velocimetry, and computational fluid dynamics simulations, to provide a detailed analysis of interfacial dynamics, flow phases/regimes, velocity field, yielded and unyielded zones, and interfacial arrest mechanisms. The flow dynamics is governed by Reynolds (
$Re$), Froude (
$Fr$) and Bingham (
$B$) numbers, the viscosity ratio (
$M$), inclination angle (
$\beta$), or their combinations, such as
$\chi \equiv 2Re/Fr^2$. As the interface evolves, our results reveal a transition from an inertial-dominated phase, characterised by linear front advancement at the injection velocity, to a viscoplastic-dominated phase, marked by deceleration and eventual interfacial arrest governed by the yield stress. The critical transition length between these phases
$(\mathcal{L} \approx 1.26 Fr^{0.14})$ is determined by a balance between inertial and buoyant stresses. Experimental findings confirm buoyancy-driven slumping in our flows, consistent with the theoretical yield number criterion (
$Y \equiv B/\chi$), with maximum interfacial arrest lengths scaling as
$L_s \sim 1/Y$. These results also classify arrested and unhalted interfacial flow regimes on a plane involving
${\chi \cos (\beta )}/{B}$ and
$Y$. Furthermore, we demonstrate that the interfacial arrest mechanism arises from interactions between buoyancy, rheology and geometry, as diminishing shear stresses promote unyielded zone expansion near the interface, progressively encompassing the viscoplastic layer and halting flow when stresses fall below the yield stress.